S. Pfuhler: search on Z-Library

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1

Detection of DNA-crosslinking agents with the alkaline comet assay

Stefan Pfuhler, Hans Uwe Wolf

Journal:

Environmental and Molecular Mutagenesis

Year:

1996

Language:

english

File:

PDF, 527 KB

english, 1996

2

Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not

Thomas R. Downs, Meredith E. Crosby, Ting Hu, Shyam Kumar, Ashley Sullivan, Katherine Sarlo, Bob Reeder, Matt Lynch, Matthew Wagner, Tim Mills, Stefan Pfuhler

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2012

Language:

english

File:

PDF, 2.10 MB

english, 2012

3

The rat bone marrow micronucleus test: Statistical considerations on historical negative control data

Igl, Bernd-Wolfgang, Bitsch, Annette, Bringezu, Frank, Chang, Steffi, Dammann, Martina, Frötschl, Roland, Harm, Volker, Kellner, Rupert, Krzykalla, Volker, Lott, Jasmin, Nern, Marlies, Pfuhler, Stefan

Journal:

Regulatory Toxicology and Pharmacology

Year:

2018

Language:

english

File:

PDF, 531 KB

english, 2018

4

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type

Paul Fowler, Katie Smith, Jamie Young, Laura Jeffrey, David Kirkland, Stefan Pfuhler, Paul Carmichael

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

5

The reconstructed skin micronucleus assay (RSMN) in EpiDerm™: Detailed protocol and harmonized scoring atlas

Erica L. Dahl, Rodger Curren, Brenda C. Barnett, Zubin Khambatta, Kerstin Reisinger, Gladys Ouedraogo, Brigitte Faquet, Anne-Claire Ginestet, Greg Mun, Nicola J. Hewitt, Greg Carr, Stefan Pfuhler, Mar

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

6

Assessment of the sensitivity of the Ames Assay to pick up true mutagens at concentrations lower than the maximum OECD TG471 guideline dose

Holland, D., Pfuhler, S.

Journal:

Toxicology Letters

Year:

2018

Language:

english

File:

PDF, 62 KB

english, 2018

7

Use of HPLC/UPLC instead of photometry for evaluation of MTT in in vitro irritation assays based on human reconstructed tissue for assessment of coloured test materials

Claudine Faller, Thomas Sieber, Pauline M. McNamee, Stefan Pfuhler, Carsten Goebel

Journal:

Year:

2009

Language:

english

File:

PDF, 159 KB

english, 2009

8

In vitro genotoxicity test approaches with better predictivity: Summary of an IWGT workshop

Stefan Pfuhler, Mick Fellows, Jan van Benthem, Raffaella Corvi, Rodger Curren, Kerry Dearfield, Paul Fowler, Roland Frötschl, Azeddine Elhajouji, Ludovic Le Hégarat, Toshio Kasamatsu, Hajime Kojima, G

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2011

Language:

english

File:

PDF, 786 KB

english, 2011

9

Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays

J. Whitwell, R. Smith, K. Jenner, H. Lyon, D. Wood, J. Clements, K. Aschcroft-hawley, B. Gollapudi, D. Kirkland, E. Lorge, S. Pfuhler, J. Y. Tanir, V. Thybaud

Year:

2015

Language:

english

File:

PDF, 5.34 MB

english, 2015

10

Re: Gi et al. 2018, In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats, Archives of Toxicology 92:3207–3221

White, Paul A., Zeller, Andreas, Pfuhler, Stefan, Johnson, George E.

Journal:

Archives of Toxicology

Year:

2019

Language:

english

File:

PDF, 527 KB

english, 2019

11

Investigation of genotoxic effects of the anti-asthmatic and anti-inflammatory drugs Apocynin and Acetosyringenin in the Salmonella typhimurium mutagenicity assay and the SCE-test with human lymphocytes

S. Pfuhler, P. Stehrer-Schmid, W. Dorsch, H. Wagner, H.U. Wolf

Journal:

Year:

1995

Language:

english

File:

PDF, 331 KB

english, 1995

12

Assessment of mechanisms driving non-linear dose–response relationships in genotoxicity testing

Guérard, M., Baum, M., Bitsch, A., Eisenbrand, G., Elhajouji, A., Epe, B., Habermeyer, M., Kaina, B., Martus, H.J., Pfuhler, S., Schmitz, C., Sutter, A., Thomas, A.D., Ziemann, C., Froetschl, R.

Journal:

Mutation Research/Reviews in Mutation Research

Year:

2015

Language:

english

File:

PDF, 1.47 MB

english, 2015

13

Emerging approaches in predictive toxicology

Zhang, Luoping, McHale, Cliona M., Greene, Nigel, Snyder, Ronald D., Rich, Ivan N., Aardema, Marilyn J., Roy, Shambhu, Pfuhler, Stefan, Venkatactahalam, Sundaresan

Journal:

Environmental and Molecular Mutagenesis

Year:

2014

Language:

english

File:

PDF, 183 KB

english, 2014

14

3.10. Carcinogenicity

Maurici, Daniela, Aardema, Marilyn, Corvi, Raffaella, Kleber, Marcus, Krul, Cyrille, Laurent, Christian, Loprieno, Nicola, Pasanen, Markku, Pfuhler, Stefan, Phillips, Barry, Prentice, David, Sabbioni,

Journal:

Alternatives to laboratory animals : ATLA

Year:

2005

Language:

english

File:

PDF, 83 KB

english, 2005

15

Effects of the formaldehyde releasing preservatives dimethylol urea and diazolidinyl urea in several short-term genotoxicity tests

Stefan Pfuhler, Hans Uwe Wolf

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2002

Language:

english

File:

PDF, 527 KB

english, 2002

16

Exercise-Induced DNA Effects in Human Leukocytes Are Not Accompanied by Increased Formation of 8-Hydroxy-2′-Deoxyguanosine or Induction of Micronuclei

Andreas Hartmann, Stefan Pfuhler, Claudia Dennog, Dietmar Germadnik, Alexander Pilger, Gunter Speit

Journal:

Free Radical Biology and Medicine

Year:

1998

Language:

english

File:

PDF, 186 KB

english, 1998

17

Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities—Report from an ECVAM workshop

Stefan Pfuhler, David Kirkland, Peter Kasper, Makoto Hayashi, Philippe Vanparys, Paul Carmichael, Stephen Dertinger, David Eastmond, Azeddine Elhajouji, Cyrille Krul, Andreas Rothfuss, Gabriele Schoen

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2009

Language:

english

File:

PDF, 1.02 MB

english, 2009

18

Automation and validation of micronucleus detection in the 3D EpiDerm human reconstructed skin assay and correlation with 2D dose responses

Chapman, K. E., Thomas, A. D., Wills, J. W., Pfuhler, S., Doak, S. H., Jenkins, G. J. S.

Journal:

Year:

2014

Language:

english

File:

PDF, 3.54 MB

english, 2014

19

Weak silica nanomaterial-induced genotoxicity can be explained by indirect DNA damage as shown by the OGG1-modified comet assay and genomic analysis

Pfuhler, Stefan, Downs, Thomas R., Allemang, Ashley J., Shan, Yuching, Crosby, Meredith E.

Journal:

Year:

2016

Language:

english

File:

PDF, 353 KB

english, 2016

20

Preface

Shareen H. Doak, Stefan Pfuhler

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2012

Language:

english

File:

PDF, 143 KB

english, 2012

21

N-acetylation of three aromatic amine hair dye precursor molecules eliminates their genotoxic potential

Zeller, A., Pfuhler, S.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.13 MB

english, 2014

22

Effect of 2-acetylaminofluorene and its genotoxic metabolites on DNA adduct formation and DNA damage in 3D reconstructed human skin tissue models

Downs, Thomas R, Arlt, Volker M, Barnett, Brenda C, Posgai, Ryan, Pfuhler, Stefan

Journal:

Year:

2019

File:

PDF, 751 KB

2019

23

Current status of the cosmetics Europe animal-free genotoxicity projects

Reisinger, K., Pfuhler, S., Fautz, R., Quedraogo, G., Latil, A., Kenny, J., Moore, C., Kühnl, J., Hewitt, N.J., Barroso, J.

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 95 KB

english, 2013

24

Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells

Allemang, Ashley, Mahony, Catherine, Lester, Cathy, Pfuhler, Stefan

Journal:

Food and Chemical Toxicology

Year:

2018

Language:

english

File:

PDF, 1.11 MB

english, 2018

25

Validation of the 3D reconstructed human skin Comet assay, an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays

Pfuhler, Stefan, Pirow, Ralph, Downs, Thomas R, Haase, Andrea, Hewitt, Nicola, Luch, Andreas, Merkel, Marion, Petrick, Claudia, Said, AndrÃ©, SchÃ¤fer-Korting, Monika, Reisinger, Kerstin

Journal:

Year:

2020

File:

PDF, 563 KB

2020

26

Comet assay in reconstructed 3D human epidermal skin models--investigation of intra- and inter-laboratory reproducibility with coded chemicals

Reus, A. A., Reisinger, K., Downs, T. R., Carr, G. J., Zeller, A., Corvi, R., Krul, C. A. M., Pfuhler, S.

Journal:

Year:

2013

Language:

english

File:

PDF, 4.01 MB

english, 2013

27

The COLIPA strategy for animal-free genotoxicity testing

Walter Diembeck, Paul Carmichael, Marilyn Aardema, Rolf Fautz, James Harvey, Nicky Hewitt, Alain Latil, Monique Marrec-Fairley, Stefan Pfuhler, Gladys Quedraogo, Kerstin Reisinger

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 81 KB

english, 2009

28

In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results

Kirkland, D., Aardema, M., Banduhn, N., Carmichael, P., Fautz, R., Meunier, J.-R., Pfuhler, S.

Journal:

Year:

2007

Language:

english

File:

PDF, 179 KB

english, 2007

29

Threshold of toxicological concern (TTC) for botanicals - Concentration data analysis of potentially genotoxic constituents to substantiate and extend the TTC approach to botanicals

Mahony, Catherine, Bowtell, Phil, Huber, Melissa, Kosemund, Kirstin, Pfuhler, Stefan, Zhu, Tingting, Barlow, Susan, McMillan, Donna A.

Journal:

Food and Chemical Toxicology

Year:

2020

File:

PDF, 1.22 MB

2020

30

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Genotoxicity. A COLIPA analysis

Stefan Pfuhler, Annette Kirst, Marilyn Aardema, Norbert Banduhn, Carsten Goebel, Daisuke Araki, Margit Costabel-Farkas, Eric Dufour, Rolf Fautz, James Harvey, Nicola J. Hewitt, Jalila Hibatallah, Paul

Journal:

Regulatory Toxicology and Pharmacology

Year:

2010

Language:

english

File:

PDF, 283 KB

english, 2010

31

Corrigendum to ‘A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Genotoxicity. A COLIPA analysis’ [Regulatory Toxicology and Pharmacology 57 (2010) 315–324]

Stefan Pfuhler, Annette Kirst, Marilyn Aardema, Norbert Banduhn, Carsten Goebel, Daisuke Araki, Margit Costabel-Farkas, Eric Dufour, Rolf Fautz, James Harvey, Nicola J. Hewitt, Jalila Hibatallah, Paul

Journal:

Regulatory Toxicology and Pharmacology

Year:

2010

Language:

english

File:

PDF, 127 KB

english, 2010

32

P XIV B.5 - P XIV B.5 The use of the alkaline comet assay to detect DNA crosslinks: Improved methodology

Stefan Pfuhler, Sieglinde Deutschenbaur, Hans-Uwe Wolf

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1997

Language:

english

File:

PDF, 224 KB

english, 1997

33

Genotoxicity of nanomaterials: Refining strategies and tests for hazard identification

Pfuhler, Stefan, Elespuru, Rosalie, Aardema, Marilyn J., Doak, Shareen H., Maria Donner, E., Honma, Masamitsu, Kirsch-Volders, Micheline, Landsiedel, Robert, Manjanatha, Mugimane, Singer, Tim, Kim, Ja

Journal:

Environmental and Molecular Mutagenesis

Year:

2013

Language:

english

File:

PDF, 111 KB

english, 2013

34

The Cosmetics Europe strategy for animal-free genotoxicity testing: Project status up-date

Pfuhler, S., Fautz, R., Ouedraogo, G., Latil, A., Kenny, J., Moore, C., Diembeck, W., Hewitt, N.J., Reisinger, K., Barroso, J.

Journal:

Toxicology in Vitro

Year:

2014

Language:

english

File:

PDF, 848 KB

english, 2014

35

ECVAM retrospective validation of in vitro micronucleus test (MNT)

Corvi, R., Albertini, S., Hartung, T., Hoffmann, S., Maurici, D., Pfuhler, S., van Benthem, J., Vanparys, P.

Journal:

Year:

2008

Language:

english

File:

PDF, 132 KB

english, 2008

36

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop

David Kirkland, Stefan Pfuhler, David Tweats, Marilyn Aardema, Raffaella Corvi, Firouz Darroudi, Azeddine Elhajouji, Hansruedi Glatt, Paul Hastwell, Makoto Hayashi, Peter Kasper, Stephan Kirchner, Ant

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 2.21 MB

english, 2007

37

Correction to: Re: Gi et al. 2018, In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats, Archives of Toxicology 92:3207–3221

White, Paul A., Zeller, Andreas, Pfuhler, Stefan, Johnson, George E.

Journal:

Archives of Toxicology

Year:

2019

Language:

english

File:

PDF, 388 KB

english, 2019

38

Pyrrolizidine alkaloids in food and phytomedicine: Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review

Schrenk, Dieter, Gao, Lan, Lin, Ge, Mahony, Catherine, Mulder, Patrick P.J., Peijnenburg, Ad, Pfuhler, Stefan, Rietjens, Ivonne M.C.M., Rutz, Lukas, Steinhoff, Barbara, These, Anja

Journal:

Food and Chemical Toxicology

Year:

2020

File:

PDF, 1.29 MB

2020

39

Metabolism of oxidative hair dyes: An overview of in vitro, in vivo, and clinical studies

Julie Skare, Gerhard Nohynek, Robert Powrie, Carsten Goebel, Stefan Pfuhler, Daniel Duche, Andreas Zeller, Marilyn Aardema, Ting Hu, Wim J.A. Meuling

Journal:

Toxicology Letters

Year:

2007

Language:

english

File:

PDF, 81 KB

english, 2007

40

A critical appraisal of the sensitivity of in vivo genotoxicity assays in detecting human carcinogens

Zeller, Andreas, Pfuhler, Stefan, Albertini, Silvio, Bringezu, Frank, Czich, Andreas, Dietz, Yasmin, Fautz, Rolf, Hewitt, Nicola J, Kirst, Annette, Kasper, Peter

Journal:

Year:

2018

Language:

english

File:

PDF, 313 KB

english, 2018

41

Evaluation of aromatic amines in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay

Holland, Daniela, Barnett, Brenda, Aardema, Marilyn, Pfuhler, Stefan

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 94 KB

english, 2013

42

In-vitro-only testing strategies for cosmetic ingredients: Utility of newly validated genotoxicity assays using human skin and fertilized hen's eggs

Desprez, Bertrand, Fautz, Rolf, Hoffmann, Sebastian, Hewitt, Nicola, Fowler, Paul, Reisinger, Kerstin, Kuehnl, Jochen, Ouédraogo, Gladys, Kenny, Julia, Pfuhler, Stefan

Journal:

Toxicology Letters

Year:

2017

Language:

english

File:

PDF, 60 KB

english, 2017

43

3.7. Genotoxicity and Mutagenicity

Maurici, Daniela, Aardema, Marilyn, Corvi, Raffaella, Kleber, Marcus, Krul, Cyrille, Laurent, Christian, Loprieno, Nicola, Pasanen, Markku, Pfuhler, Stefan, Phillips, Barry, Sabbioni, Enrico, Sanner,

Journal:

Alternatives to laboratory animals : ATLA

Year:

2005

Language:

english

File:

PDF, 116 KB

english, 2005

44

Simulated skin metabolism and impact on genotoxic hazard of two hair dye precursors

Andreas Zeller, Linda Corbino, Celine Procureur, Laurence Richoz, Stefan Pfuhler

Journal:

Toxicology Letters

Year:

2007

Language:

english

File:

PDF, 67 KB

english, 2007

45

Genotoxicity assessment of nanomaterials: recommendations on best practices, assays and methods

Elespuru, Rosalie, Pfuhler, Stefan, Aardema, Marilyn, Chen, Tao, Doak, Shareen H, Doherty, Ann, Farabaugh, Christopher S, Kenny, Julia, Manjanatha, Mugimane, Mahadevan, Brinda, Moore, Martha M, Ouédra

Journal:

Toxicological Sciences

Year:

2018

Language:

english

File:

PDF, 1.07 MB

english, 2018

46

3.10. Carcinogenicity

Maurici, Daniela, Aardema, Marilyn, Corvi, Raffaella, Kleber, Marcus, Krul, Cyrille, Laurent, Christian, Loprieno, Nicola, Pasanen, Markku, Pfuhler, Stefan, Phillips, Barry, Prentice, David, Sabbioni,

Journal:

Alternatives to laboratory animals : ATLA

Year:

2005

File:

PDF, 83 KB

2005

47

A Comparison of Classical and 21 st Century Genotoxicity Tools: A Proof of Concept Study of 18 Chemicals Comparing In Vitro Micronucleus, ToxTracker and Genomicsâbased Methods ( TGxâDDI , Whole Genome Clustering and Connectivity Mapping)

Allemang, Ashley, De Abrew, K. Nadira, Shan, Yuqing K., Krailler, Jesse M., Pfuhler, Stefan

Journal:

Environmental and Molecular Mutagenesis

Year:

2020

File:

PDF, 2.32 MB

2020

48

Animal-free genotoxicity testing: The COLIPA program

S. Pfuhler, P. Carmichael, P. Fowler, R. Curren, C. Krul, G. Ouedraogo, K. Reisinger, M. Marrec-Fairley, A. Kirst, N. Hewitt

Journal:

Toxicology Letters

Year:

2010

Language:

english

File:

PDF, 82 KB

english, 2010

49

Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop

Kirkland, David, Zeiger, Errol, Madia, Federica, Gooderham, Nigel, Kasper, Peter, Lynch, Anthony, Morita, Takeshi, Ouedraogo, Gladys, Parra Morte, Juan Manuel, Pfuhler, Stefan, Rogiers, Vera, Schulz,

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2014

Language:

english

File:

PDF, 837 KB

english, 2014

50

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. II. Importance of accurate toxicity measurement

Paul Fowler, Robert Smith, Katie Smith, Jamie Young, Laura Jeffrey, David Kirkland, Stefan Pfuhler, Paul Carmichael

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

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